[A case of urticaria during Carsil treatment]. View abstract. [Effect of Silybum marianum oil and legalon on lipid peroxidation and liver antioxidant systems in rats intoxicated with carbon tetrachloride]. Kuo YJ, Chang HP, Chang YJ, Wu HH, Chen CH. Himalaya for AMLA. In particular, it. Milk thistle is commonly used for everything from weight loss to skin health to promoting breast milk production. Bioorg Med Chem Lett 2000;10:157-60. Nephrol.Dial.Transplant. It is possibly effective in diabetes and indigestion ( dyspepsia ). 2011;187(8):485-491. In one study, S. marianum supplementation was observed to increase insulin sensitivity in much the same way as available medications, such as thiazolidinedione. Ghiasian M, Nafisi H, Ranjbar A, Mohammadi Y, Ataei S. Antioxidative effects of silymarin on the reduction of liver complications of fingolimod in patients with relapsing-remitting multiple sclerosis: a clinical trial study. Phytomedicine. 1982;17:51721. Moosavifar, N., Mohammadpour, A. H., Jallali, M., Karimiz, G., and Saberi, H. Evaluation of effect of silymarin on granulosa cell apoptosis and follicular development in patients undergoing in vitro fertilization. Drug Metab Dispos 2008;36(9):1909-1916. 2019;14(9):e0221683. 2015;43(9):1353-9. It may have protective effects on the liver, preventing damage. 2016;35(5):1091-5. Lasers Surg Med 2021. Studies have shown a decrease in blood sugar levels and an improvement in cholesterol in people with type 2 diabetes. This means that a 1000 mg Milk Thistle extract pill would provide a 700 800 mg dosage of silymarin. Milk thistle (Silybum marianum) is a medicinal plant from the Asteraceae family. People suffering from diabetes must avoid the consumption of milk thistle as it can lower the blood sugar level in the person. Effect of silymarin treatment on circulating bilirubin and cardiovascular disease risk factors in healthy men: a single-blind, randomized crossover trial. By Brittany Lubeck, RD 5th ed. View abstract. View abstract. Therefore, at this time, its unclear if milk thistle has the same effects in people without diabetes and if it will be used to naturally lower cholesterol levels in the future. Liver damage caused by cancer drugs. Carcinogenesis 2001;22:1399-403. Voroneanu L, Nistor I, Dumea R, Apetrii M, Covic A. Silymarin in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials. Prostate 6-1-2010;70(8):848-855. Free radical scavenging and antioxidative properties of 'silibin' complexes on microsomal lipid peroxidation. Meta-analysis: phytotherapy of functional dyspepsia with the herbal drug preparation STW 5 (Iberogast). View abstract. Milk thistle: Effects on liver disease and cirrhosis and clinical adverse effects. PLoS One. Your email address will not be published. Achufusi TGO, Patel RK. Gynecol Endocrinol 2007;23:117-22. Silymarin is believed to have antioxidant properties. 2012;308(3):274-82. doi:10.1001/jama.2012.8265. Jiao Z, Shi XJ, Li ZD, et al. Otolaryngology - Head and Neck Surgery 2011;145:904-9. Acta Med Hung. Hasani-Ranjbar, S., Nayebi, N., Moradi, L., Mehri, A., Larijani, B., and Abdollahi, M. The efficacy and safety of herbal medicines used in the treatment of hyperlipidemia; a systematic review. Kawaguchi-Suzuki M, Frye RF, Zhu HJ, et al. View abstract. Milk thistle has traditionally been used as both an edible vegetable and as a medicinal agent. 1998;48(11):1104-1106. Most experts recommend that people with NAFLD lose weight to reduce fat build-up in the liver and lower their cholesterol to reduce the risk of heart disease. Milk thistle contains a chemical called silymarin. Mol Med Rep. 2016 Apr;13(4):3243-8. doi:10.3892/mmr.2016.4887. Schrieber, S. J., Hawke, R. L., Wen, Z., Smith, P. C., Reddy, K. R., Wahed, A. S., Belle, S. H., Afdhal, N. H., Navarro, V. J., Meyers, C. M., Doo, E., and Fried, M. W. Differences in the disposition of silymarin between patients with nonalcoholic fatty liver disease and chronic hepatitis C. Drug Metab Dispos. You may opt-out of email communications at any time by clicking on Summary, Evidence Report/Technology Assessment: Number 21, September 2000. Int J Mol Sci. Feng N, Luo J, Guo X. Silybin suppresses cell proliferation and induces apoptosis of multiple myeloma cells via the PI3K/Akt/mTOR signaling pathway. Manna SK, Mukhopadhyay A, Van NT, Aggarwal BB. View abstract. Med Klin. 1996;62(5):187-193. Some people may be allergic to milk thistle. Effect of silymarin in the treatment of allergic rhinitis. Memorial Sloan-Kettering Cancer Center: About Herbs: Milk thistle., Natural Standard Patient Monograph: Milk thistle.. There are other supplements that work similarly to milk thistle. 1998;20(3):471-479. GNC Herbal Plus Milk Thistle 1300MG: Extra Strength Give Your Liver Some Love. This herb contains active compounds called silymarin and silybin that the "Physicians' Desk Reference for Herbal Medicines" describes as hepatoprotective, meaning they protect the liver by blocking toxin-binding receptor sites in the cells of the organ's outer membrane 2.A review published in the "World Journal of Gastroenterology" in May 2011 finds that both silymarin . BOGO 50% Off Mix-and-Match Add to Cart J.Clin.Virol. Thank you, {{form.email}}, for signing up. Fried MW, Navarro VJ, Afdhal N, et al. Silymarin may help reduce the risk for cancer development (including breast cancer) by boosting the immune system, fighting DNA damage and reversing cancerous tumor growth. Most studies have used up to 800 mg per day. Life Sci 5-23-2008;82(21-22):1070-1076. 1,300 mg: Teens 14-18 years: 1,300 mg: Adults 19-50 years: 1,000 mg: Adult men 51-70 years: 1,000 mg: . When possible, choose a supplement that has been tested by a trusted third party, such as USP, ConsumerLabs, or NSF, and be sure to discuss with your healthcare provider. This might cause more side effects from some medications. 2020. Flora K, Hahn M, Rosen H, Benner K. Milk thistle (Silybum marianum) for the therapy of liver disease. Liver damage caused by chemicals. Doehmer J, Weiss G, McGregor GP, Appel K. Assessment of a dry extract from milk thistle (Silybum marianum) for interference with human liver cytochrome-P450 activities. In another study, mothers taking 600-milligram capsules of fenugreek seeds three times daily for a month had an increase in breast milk production of 20%although that wasn't a . Can Taking 1000 mg of Milk Thistle Every Day be Considered Too Much? Trigonella foenum-graecum(fenugreek)also is used for this reason. Giorgi, V. S., Peracoli, M. T., Peracoli, J. C., Witkin, S. S., and Bannwart-Castro, C. F. Silibinin modulates the NF-kappab pathway and pro-inflammatory cytokine production by mononuclear cells from preeclamptic women. There is also concern that milk thistle might affect estrogen levels. Par, A., Roth, E., Miseta, A., Hegedus, G., Par, G., Hunyady, B., and Vincze, A. Milk Thistle Has Anti-Aging Properties. Silybum marianum has been observed to affect cholesterol production in the liver and act on the cytochrome p450 liver enzyme pathway. A double-blind controlled randomized clinical trial of phototherapy plus oral Silybum marianum product versus phototherapy alone. Before taking milk thistle, talk to your healthcare provider if you are taking warfarin. View abstract. Anon. Research on milk thistle use for specific conditions shows: Milk thistle might play a role in treating certain liver conditions. Kim DH, Jin YH, Park JB, Kobashi K. Silymarin and its components are inhibitors of beta-glucuronidase. Look for a high-quality product thats between 50150 milligrams of pure milk thistle extract per capsule so you can adjust the amount you are taking depending on your needs. Gharagozloo, M., Moayedi, B., Zakerinia, M., Hamidi, M., Karimi, M., Maracy, M., and Amirghofran, Z. Eurich, D., Bahra, M., Berg, T., Boas-Knoop, S., Biermer, M., Neuhaus, R., Neuhaus, P., and Neumann, U. Dehmlow, C., Murawski, N., and de Groot, H. Scavenging of reactive oxygen species and inhibition of arachidonic acid metabolism by silibinin in human cells. This makes it very hard to establish a standard dose. What is milk thistle? View abstract. Zhang, J., Luan, Q., Liu, Y., Lee, D. Y., and Wang, Z. 2018;8:65-74. J Herb Pharmacother 2002;2:11-7. Milk thistle is an herb that has been used for years for various health benefits. View abstract. This article will explore the uses of milk thistle and research on its potential benefits. El-Kamary, S. S., Shardell, M. D., Abdel-Hamid, M., Ismail, S., El-Ateek, M., Metwally, M., Mikhail, N., Hashem, M., Mousa, A., Aboul-Fotouh, A., El-Kassas, M., Esmat, G., and Strickland, G. T. A randomized controlled trial to assess the safety and efficacy of silymarin on symptoms, signs and biomarkers of acute hepatitis. 2010;154(3):239-244. Curr Ther Res 1993;53(5):533-545. View abstract. These side effects may be mild or severe. Vidlar, A., Vostalova, J., Ulrichova, J., Student, V., Krajicek, M., Vrbkova, J., and Simanek, V. The safety and efficacy of a silymarin and selenium combination in men after radical prostatectomy - a six month placebo-controlled double-blind clinical trial. Ahmed S, Ullah N, Parveen S, et al. Mastron JK, Siveen KS, Sethi G, Bishayee A.Silymarin and hepatocellular carcinoma: a systematic, comprehensive, and critical review. This is a somewhat high dose that can act as a natural liver detox. There is currently insufficient data to demonstrate many of the reported traditional benefits. People with diabetes often have high cholesterol. Life Sci 5-25-2001;69(1):75-86. But experts say that the evidence isnt conclusive. Milk thistle (silymarin) is a flowering herb related to the daisy and ragweed family. Historically, people have used milk thistle for liver disorders and gallbladder problems. View abstract. View abstract. Its also known as St. Marys thistle, holy thistle and silybum. per day. Weyhenmeyer, R., Mascher, H., and Birkmayer, J. 5. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. View abstract. The first recorded use dates back to Ancient Greece when the plant was used to treat poisonous snake bites. View abstract. Swelling (inflammation) of the liver caused by the hepatitis B virus (hepatitis B). Med Sci Ress 1995;23:31-33. View abstract. However, one area of milk thistle research focuses on how it affects bone marrow, which contributes to overall bone health but also has implications in treating diseases like multiple myeloma, a type of blood cancer. Other studies looking at milk thistle for cirrhosis have found conflicting results. Milk thistle is not recommended for children. People sometimes use milk thistle for hepatitis C, a viral infection of the liver. A skin disorder that causes white patches to develop on the skin (vitiligo). Milk thistle might affect how quickly the liver breaks down some medications. 2.2 pounds). doi:10.1097/CAD.0000000000000211. Free shipping for many products! However, few of these claims are supported by solid evidence. Barzaghi, N., Crema, F., Gatti, G., Pifferi, G., and Perucca, E. Pharmacokinetic studies on IdB 1016, a silybin- phosphatidylcholine complex, in healthy human subjects. Substances in milk thistle may reduce blood sugar, a concern for people living with diabetes.Milk thistle may change the way your liver metabolizes certain drugs, like blood thinners, antibiotics, and anti-inflammatory medications. 2002;18(3):265-269. 2006;34(1):69-74. Before taking milk thistle, talk to your healthcare provider if you are taking raloxifene. Early research shows that taking milk thistle leaf extract by mouth three times daily for 8 weeks has a limited effect on OCD symptoms. View abstract. Ebrahimpour koujan S, Gargari BP, Mobasseri M, Valizadeh H, Asghari-jafarabadi M. Effects of Silybum marianum (L.) Gaertn. 2014;11(2):167-74. doi:10.1900/RDS.2014.11.167, Rambaldi A, Jacobs BP, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases. Planta Med 1980;38(3):227-237. Finally, keep in mind that, although many holistic practitioners recommend milk thistle for dogs to help promote liver health, its best to talk to your vet before starting supplementation to keep your furry friends safe. Randomized controlled study of the efficacy and tolerability of a short course of IdB 1016 in the treatment of chronic persistent hepatitis. Gazz Med Ital 1974;133:628-635. Valenzuela, A., Lagos, C., Schmidt, K., and Videla, L. A. Silymarin protection against hepatic lipid peroxidation induced by acute ethanol intoxication in the rat. Feher J, Deak G, Muzes G, et al. All rights reserved. While taking milk thistle doesn't seem to improve the overall severity of NASH, it may reduce scarring of the liver. For ongoing use and liver support, take 50 to 150 milligrams daily. 1-11-2009;150(2):73-79. View abstract. Seeff LB, Curto TM, Szabo G, et al. Ask your doctor for advice. J Biochem Mol Toxicol 2021. Br J Clin Pharmacol 2023;89(4):1329-1337. Enable Accessibility Save $10 on $75 Code: . Taking milk thistle along with diabetes medications might cause your blood sugar to be too low. Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials. The most common side effects arent serious and include gastrointestinal upset, such as a mild laxative effect. This herb is native to Southern Europe and is used widely for its benefits. information and will only use or disclose that information as set forth in our notice of Biochem.Pharmacol 10-12-1995;50(8):1313-1316. Some medications used for lowering cholesterol include atorvastatin (Lipitor), fluvastatin (Lescol), lovastatin (Mevacor), pravastatin (Pravachol), and rosuvastatin (Crestor). View abstract. Taking milk thistle along with estrogens might decrease the effectiveness of estrogen pills. Milk thistle has been investigated for its ability to alter blood sugar levels and has been observed to support conventional diabetes treatment. Pharmacol Toxicol 2000;86:250-6. Get the facts on milk thistle for the liver. East Mediterr.Health J. Before taking milk thistle, talk to your healthcare provider if you are taking tamoxifen.

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