It is thus important to lose weight. 2020;72(3):125-130. doi:10.4081/reumatismo.2020.1272, Litwiniuk M, Krejner A, Speyrer MS, Gauto AR, Grzela T. Hyaluronic acid in inflammation and tissue regeneration. Bukhari SNA, Roswandi NL, Waqas M, et al. Replenishing the skin with hyaluronic acid is effective in combating the natural aging process. The results of the study are quite clear and quite enlightening: anything up to 300 kDa offers a good degree of penetration, with 50-300 kDa being ideal for anti-ageing and lower molecular weights (800-10 kDa) being ideal for cellulite removal and water retention reduction. Hyaluronic acid is now of the most important anti-ageing actives in face skin care creams and serums - and is also found in some body products. Journal of Medicinal Food. Kristina Liu MD, Janelle Nassim MD. 2020;16(3):366.e1-366.e5. Hyaluronic acid does not lead to weight gain directly, as it has no caloric value. The reality is that even with the best technology in the world, your skin needs 5, 10, 15 regular (ie weekly), strong, deep-acting, never painful treatments, for good, long-term results, produced naturally by stimulating the connective and adipose tissues, rather than burning them. The sodium hyaluronate form is listed as an ingredient in most skin care products due to its lower molecular weight, allowing it to penetrate deeper into the skin. 2010;29(5):535-539. doi:10.1007/s10067-010-1372-z, Yang JJ, Zhang XM. A randomized multicenter clinical evaluation of sequential application of 0.3% and 0.15% hyaluronic acid for treatment of dry eye. Hyaluronic acid is naturally produced by the body and is used in. Get useful, helpful and relevant health + wellness information. As we mentioned above, we must really know what we are doing with lower molecular weight HA, so shoving a 20 kDa HA into the skin is not the solution to everything, as this may prove either beneficial or irritating. The hyaluronic acid in supplements often contains 2 MDa of hyaluronic acid, which should not be mistaken for the form of hyaluronic acid 20 MDa that can gather in the tissue and develop into cellulite. One study has shown that LMWHA can penetrate deeper into the skin compared to HMWHA, which does not pass through the skin. 1 part HA and 999 parts water and perhaps some other active or inactive ingredients. Hyaluronic Acid Suppositories UK, hyaluronic acid vaginal gel (Hyalofemme) is used to ease vaginal dryness Italy, hyaluronic acid 5 mg suppositories with vitamin A & E were found to be a safe and effective alternative to estrogen Primary End point: Visual Analogue Scale Secondary End points: itching, burning, dyspareunia, irritation Cellulite before and after pictures on Instagram? So you can combine oral HA and loads of water for improved skin hydration and anti-ageing. No reproduction without written permission (plagiarising web pages will be reported to search engines for removal from their index). This is, however, a very naive thought, based on several misunderstandings: Supplements contain the proper hyaluronic acid, i.e. Hyaluronic acid is found throughout most tissues in the body, with the greatest concentration in the skin. Just one tablespoon of peanut butter has four grams of protein, making it a good source of protein for building muscle. It isn't possible to lead to weight gain because of the lack of calories in hyaluronic acid. The length of the hyaluronic acid molecule can range from 2 to 50,000 disaccharides, with a molecular weight ranging from 802 to ~20,000,000 Da. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289781/. However, the study was limited because it did not have a placebo group. doi:10.1186/s12937-016-0128-2, Simental-Menda M, Snchez-Garca A, Vilchez-Cavazos F, Acosta-Olivo CA, Pea-Martnez VM, Simental-Menda LE. Examples of such foods are bone broth, organ meats and joint cartilage. 2022;66(1):58-67. doi:10.1007/s10384-021-00885-x, Yang YJ, Lee WY, Kim YJ, Hong YP. The Journal of clinical and aesthetic dermatology. Although not all of these side effects may occur, if they do occur they may need . After, we have determined spectral features of HA by which they can be detected in the skin. Your doctor might suggest hyaluronic acid . In addition to the conditions listed above, some people use HA to support the following conditions, although theres a lack of data demonstrating HAs efficacy for some: No side effects were noted in a review of several safety studies of HA. Since HA was used in combination with chondroitin sulfate, the effect of HA alone when combined with PPI therapy is unclear. Hyaluronic acid supplements work to improve the appearance of skin wrinkles, other signs of aging, and joint problems like osteoarthritis. Food and Drug Administration. Furthermore, your bodys natural production of hyaluronic acid may decrease with age. Balms and serums seem to focus on hyaluronic acid's ability to ease skin redness and reduce wrinkles while oral supplements focus on the benefits of hyaluronic acid on the joints. While pregnant do stay away from retinols which are anti aging. Efficacy: As with any medical / aesthetic treatment or skin product,results vary from person to person depending on lifestyle, genetics, state of health (how each individual body responds to treatment), so specific results cannot be guaranteed. Published April 2015. Hypochlorhydria, or low stomach acid, is a commonly overlooked problem that is linked to other diseases like stomach cancer, asthma and rheumatoid arthritis. It's also used in moisturizing creams, lotions, ointments and serums. Molecular weights below 50 kDa have to be used carefully, as they have quite varying biological effects, according to size. Pharmaceutical Biology. Plus, hyaluronic acid contains no calories, so it cannot directly lead to weight gain either. It is the smallest molecularly, will penetrate deepest, exfoliate, brighten and trigger collagen and fibroblast production. Hyaluronic acid, an efficient biomacromolecule for treatment of fi inflammatory skin and joint diseases: A review of recent developments and critical appraisal of preclinical and clinical investigations. . Comparative efficacy of intra-articular hyaluronic acid and corticoid injections in osteoarthritis of the first carpometacarpal joint: results of a 6-month single-masked randomized study, Oral hyaluronan relieves wrinkles and improves dry skin: a 12-week double-blinded, placebo-controlled study, Hyaluronic acid: a key ingredient in the therapy of inflammation, Efficacy and safety of hyaluronic acid in the management of osteoarthritis: evidence from real-life setting trials and surveys, A randomized multicenter clinical evaluation of sequential application of 0.3% and 0.15% hyaluronic acid for treatment of dry eye, A meta-analysis of the efficacy of hyaluronic acid eye drops for the treatment of dry eye syndrome, The role of oral formulation of hyaluronic acid and chondroitin sulphate for the treatment of the patients with laryngopharyngeal reflux, Efficacy of hyaluronic acid gel and spray in healing of extraction wound: a randomized controlled study, Efficacy and safety of a hyaluronic acid-containing cream in the treatment of chronic, venous, or mixed-origin leg ulcers: a prospective, multicenter randomized controlled trial, Oral intake of a liquid high-molecular-weight hyaluronan associated with relief of chronic pain and reduced use of pain medication: results of a randomized, placebo-controlled double-blind pilot study, A randomized doubleblind clinical trial to evaluate the efficacy of chlorhexidine, antioxidant, and hyaluronic acid mouthwashes in the management of biofilminduced gingivitis, Serum hyaluronic acid levels do not explain morning stiffness in patients with fibromyalgia, Clinical efficacy of glucosamine plus sodium hyaluronate for osteoporosis complicated by knee osteoarthritis and Its influence on joint function and bone metabolic markers, Intravesical hyaluronic acid treatment in recurrent urinary tract infections in children with spina bifida and neurogenic bladder, Polycarbophil vaginal moisturizing gel versus hyaluronic acid gel in women affected by vaginal dryness in late menopausal transition: a prospective randomized trial, Efficacy and safety of repeated courses of hyaluronic acid injections for knee osteoarthritis: a systematic review, Safety of a single intra-articular injection of LBSA0103 hyaluronic acid in patients with osteoarthritis of the knee: a multicenter, single-arm, prospective, cohort study, Hyaluronic acid injection therapy for osteoarthritis of the knee: concordant efficacy and conflicting serious adverse events in two systematic reviews, Effects of hyaluronic acid on bleeding following third molar extraction, Effect of ultrasonic degradation of hyaluronic acid extracted from rooster comb on antioxidant and antiglycation activities, Versatile strategies for bioproduction of hyaluronic acid driven by synthetic biology, Targeting hyaluronic acid and peritoneal dissemination in colorectal cancer, Hyaluronic acid for the treatment of airway diseases in children: little evidence for few indications, Hyaluronic acid versus dexamethasone for the treatment of recurrent aphthous stomatitis in children: efficacy and safety analysis, Absorption, distribution, metabolism and excretion of hyaluronic acid during pregnancy: a matter of molecular weight, Nutraceutical approach to chronic osteoarthritis: from molecular research to clinical evidence, Oral hyaluronan relieves knee pain: a review, Effect of glucosamine and chondroitin sulfate in symptomatic knee osteoarthritis: a systematic review and meta-analysis of randomized placebo-controlled trials, Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study, Bioavailable turmeric extract for knee osteoarthritis: a randomized, non-inferiority trial versus paracetamol, A pilot, randomized, double-blind, placebo-controlled trial to assess the safety and efficacy of a novel Boswellia serrata extract in the management of osteoarthritis of the knee, Efficacy and safety of fish oil in treatment of knee osteoarthritis, The effect of oral low molecular weight liquid hyaluronic acid combination with glucosamine and chondroitin on knee osteoarthritis patients with mild knee pain, Effect of an oral preparation containing hyaluronic acid, chondroitin sulfate, hydrolyzed collagen type II and hydrolyzed keratin on synovial fluid features and clinical indices in knee osteoarthritis. Vigrx Plus is made of all-natural ingredients that work together to combat the effects of erectile dysfunction. Hyaluronic acid: a review on its biology, aspects of drug delivery, route of administrations and a special emphasis on its approved marketed products and recent clinical studies. Dermatology and Therapy. A diet rich in vegetables (magnesium) and fruit (ascorbic acid) is supposed to help boost natural HA production. Clinical Colorectal Cancer. Concentrated cellulite creams act less fast but they offer far better value for money than treatments. Creams however, are a different matter, and HA can actually increase the instability of a cream. Hyaluronic acid, a promising skin rejuvenating biomedicine: A review of recent updates and pre-clinical and clinical investigations on cosmetic and nutricosmetic effects. (https://pubmed.ncbi.nlm.nih.gov/33278954/). 2015;15(1). It presents a high molecular specificity to distinguish exogenous molecules from skin constituents. However, it is important to note that some people may experience temporary water retention after receiving hyaluronic acid injections, such as joint injections for osteoarthritis or eye injections. Over-the-counter hyaluronic acid serums and products applied on your skin (creams, lotions, etc.) Hyaluronic acid is a naturally occurring substance in the body and is used in cosmetic treatments and medical procedures for its hydrating and lubricating properties. Thus, such a hyaluronan molecule of 10,000 repeats could extend to 10 m if stretched from end to end, a length approximately equal to the diameter of a human erythrocyte. 2019;7(3):495-499. doi:10.3889/oamjms.2019.086. Its molecule forms a three-dimensional network that acts like a sponge that literally traps water around and inside its folds. or in eye care products are considered safe. Combine peoples ignorance, extreme marketing hype and greedy skincare companies and what do you get? Sometimes they use huge concentrations, which are unnecessary or even counterproductive. Medicine. As HA stimulates skin repair and hydration, and as our skin produces less and less as we age, it goes without saying that we would like to add some HA into the skin in the form of a serum, cream or gel. The lower the molecular weight, the deeper HA can penetrate into the skin. Ideally you should drink two litres of water a day. It's more or less a little sponge of a molecule. So we could argue that the only really bad type of HA in anything other than joints and padding tissues (e.g. Due to such risk factors, HA supplementation has gained popularity in the health, food, and cosmetic industries. This site is protected by reCAPTCHA and the Google Read More However, even if supplements are third-party tested, that doesnt mean they are safe for all or effective in general. This article will primarily focus on the oral supplement use of HA. While HA as a dietary supplement exhibits no side effects, potential side effects may occur depending on the application method, such as an injection into the joint or topical application. Store HA supplement in a cool, dry place and keep HA away from direct sunlight. So I started taking supplement that contains Hyaluronic Acid (HA), and after few days I have had extreme Acid Reflux. It thereby reduces photo aging. But look for something that has hyaluronic acid in it which is a natural chemical our body makes which helps retains moisture by 1000x its weight. The first step, was the spectral characterization of these HA. apply a real cellulite cream, i.e. It is commonly said that HA can absorb 1,000 times its own weight in water - but that only applies to high molecular weight HA. Of course, the aesthetics industry is already full of myths, inaccuracies, platitudes and hallucinations, so the advent of AI does not make much of a difference. 2016;5(1). Hyaluronic acid supplements taken by mouth are also considered safe (but you should still tell your healthcare provider about them, as you would for any other medication, vitamin or supplement). These include reducing arthritis pain, improving skin health and more. Clinical, Cosmetic and Investigational Dermatology. Doctors recommend these supplements to help manage other health issues like insomnia, urinary tract infections, and chronic pains. Cross-linked HA is a man-made invention to create a more stable and more hydrating HA, but it unfortunately has poorer penetration capability, as the molecule is fatter and cannot cross the epidermis very easily. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777704/. Policy. (https://pubmed.ncbi.nlm.nih.gov/19636067/). But what is hyaluronic acid, what does it do, how does it work and what is really the best type of hyaluronic acid? On the other hand, intra-articular (within the joint) injection of high molecular weight HA (HMWHA) is used to treat osteoarthritis due to its anti-inflammatory property and its high molecular weight that allows it to bind to large amounts of water.. Hyaluronic acid is available in the following dosage forms: As hyaluronic acid is derived from animals, if you are allergic to poultry or eggs, look for vegan sources of hyaluronic acid derived from microbial fermentation. 2020;243:116441. doi:10.1016/j.carbpol.2020.116441, Gupta RC, Lall R, Srivastava A, Sinha A. Hyaluronic acid: molecular mechanisms and therapeutic trajectory. The molecules hydrophilic properties also make it an excellent lubricant, which is why it is commonly used in joint injections to treat osteoarthritis. Overall, hyaluronic acids ability to retain water is what makes it a valuable ingredient in skin care products, as well as a crucial component of the bodys natural hydration and lubrication systems. The substance that is naturally produced by your body is called hyaluronan. 2015;82(2):116-121. doi:10.1016/j.jbspin.2014.08.008, Hsu TF, Su ZR, Hsieh YH, et al. For this reason, it's actually used as a tumor marker for monitoring cancer proliferation. Bioavailable turmeric extract for knee osteoarthritis: a randomized, non-inferiority trial versus paracetamol. Hyaluronic acid is similar to a substance that occurs naturally in the joints. 6. Hyaluronic acid is widely used as an ingredient in fillers that repair or conceal scars left behind by acne. A similar 12-week double-blind, randomized, placebo-controlled study conducted in 41 Taiwanese people aged 30 to 65 revealed that taking a 120 milligram (mg) HA capsule by mouth for 12 weeks improved skin wrinkles compared to the placebo. VigRX has been around since 2001 and has years of experience creating. Hyaluronic . Eye health, especially for treating dry eyes. Anti-obesity potential of enzymatic fragments of hyaluronan on high-fat diet-induced obesity in C57BL/6 mice. https://www.health.harvard.edu/blog/the-hype-on-hyaluronic-acid-2020012318653. Fear of weight gain is one of the main factors contributing to the poor compliance seen with hormone replacement therapy (HRT). Hyaluronic acid has beneficial properties when used on your skin. Top 10 Benefits of Alpha-Lipoic Acid Encourages normal thyroid hormone levels Supports healthy nerves Promotes normal heart health Protects muscles from exercise-related stress Supports the liver Promotes a strong brain and sharp memory Encourages healthy skin Promotes graceful aging Maintains healthy blood glucose levels A randomized controlled study of 100 people with osteoarthritis of the first carpometacarpal (thumb) joint showed that the intra-articular (within the joint) HA injections were superior to betamethasone (a corticosteroid) injections in improving joint function and pain. In addition,LMW hyaluronan itself is a penetration absorber for other active ingredients in body / face creams. Product classification. Hyaluronic acid: water retention, anti-aging, skin tightening, cellulite and weight gain. 2018;48(2):168-175. doi:10.1016/j.semarthrit.2018.01.009, Jang KM, Park YG, Choi WK, et al. Other actives inhibit the action of the bodys enzymes that break down HA, called, hyaluronidases. A typical hyaluronic acid polymer that is found in the human joint synovial fluid, i.e. Hyaluronic acid is very good at retaining water. Effect of an oral preparation containing hyaluronic acid, chondroitin sulfate, hydrolyzed collagen type II and hydrolyzed keratin on synovial fluid features and clinical indices in knee osteoarthritis. It also has the ability to attach itself to cells, which is why targeted delivery of medications using hyaluronic acid is a major topic of study. Guidelines for using intra-articular (within the joint) HA injection vary. Nutrients. The heart benefits seem strongest when . Fouladi-Nashta AA, Raheem KA, Marei WFA, et al. 2021;22(1). Hyaluronic acid is the skins most important hydration factor. 2021;22(23):12920. doi:10.3390/ijms222312920, Oe M, Tashiro T, Yoshida H, et al. This disaccharide has a molecular weight of 401.1 Dalton (Da). Only supplements voluntarily submitted for testing are eligible for certification. That is why hyaluronic acid has become a popular ingredient in skin care products, as it is believed to help restore and maintain the skins youthful appearance. Right now, its most often used for skin, joint and eye health. Privacy Policy and Terms of Service apply. This is a key step in how wounds heal on your body. Getting off and not going back. Rooster combs (the red, Mohawk-like growth on top of a roosters head and face) are also a common source. Peanut butter is also a good source of monounsaturated fat and antioxidants as well as vitamins and minerals that will help your body stay healthy and function properly. However, it is important to note that the study was limited due to a smaller sample size. However, further research with large sample sizes is needed to determine the effectiveness of HA on dry eye disease. UV radiation from the sun tends to diminish hyaluronic acid, leading to skin dryness and inflammation. By Ishani Ghotikar, M.Sc, CSN There is no proof that hyaluronic acid injection, topical treatment, or ingestion harms the liver. February 6, 2023 - Updated on March 6, 2023, Most-Asked Questions About Hyaluronic Acid and Weight Gain. According to research, topical hyaluronic acid results in skin hydration of up to 96% when used as a lotion, serum, and cream. Our expert physicians and surgeons provide a full range of dermatologic, reconstructive and aesthetic treatments options at Cleveland Clinic. Home > Nutrition > Does Hyaluronic Acid Cause Weight Gain? Frontiers in bioengineering and biotechnology. Plus plenty of inaccuracies, misinformation and a healthy added dose of literally made up stuff - what AI experts call AI hallucinations. Yes, I take something similar to hyaluronic acid and I gained 7 kg on it. (1), However, it has never been reported to cause weight gain. Hyaluronic Acid and Controlled Release: A Review. What Happens If I Take Too Much Hyaluronic Acid ? Open Access Maced J Med Sci. Trademarks: Meso-CRF, LipoTherapeia and Celluenceare registered trademarks in the UK & EU and belong to LipoTherapeia Ltd. All rights to the usage of those trademarks and copyrights are strictly reserved and are only allowed with prior written approval. Trang Tran, PharmD, is a pharmacist who is passionate about integrative health. As age increases, the body produces less and less hyaluronic acid, which can lead to dryness and wrinkles in the skin. Int J Environ Res Public Health. (https://pubmed.ncbi.nlm.nih.gov/32517278/). Non-medical: No information, treatment or product on this website aims to treat or diagnose any medical condition or to provide/replace medical advice. A few of the different ways (available over-the-counter) that you can take hyaluronic acid include: Hyaluronic acid is also available by prescription in the following forms: Remember, only trained and qualified medical professionals should give injections. Thus, bone broth is a source of hyaluronic acid. Published July 1, 2012. Well, for one, hyaluronic acid has a "high molecular weight" in its natural state, making it too large to actually sink into the skin. Advertising on our site helps support our mission. Its also great for helping improve overall skin flexibility and elasticity (meaning it makes your skin more stretchy and soft). Food sources of phytoestrogens include the following: Industrial uses of HA utilize either low or high molecular weight HA. However, more concentrated products can contain up to 2% HA. Top 5 Reasons to Try Hyaluronic Acid For Vaginal Dryness. Hyaluronic acid supplements also help, as the HA in them does find its way into the skin (and joints), helping hydrate and nourish the body from within. Most polyphenols can do that: they prolong the useful life of HA in the skin and inhibit its early or excessive degradation by hyaluronidases. These ingredients may help to increase libido levels, give stronger erections that last longer, and they may help boost the production of testosterone. Eur Rev Med Pharmacol Sci. Joint health, especially for treating arthritis and soft tissue injuries. Small molecular weight hyaluronic acid is any size from 20 to 300 kDa and research is suggesting any size of hyaluronic acid above 50 kDa cannot cause your skin pro-ageing inflammation. Although an increase in weight can be a result of rehydration, (which in turn may alleviate some of the effects of skin ageing), many women consider weight gain to be cosme Brazilian Journal of Medical and Biological Research. A study of 51 people aged 25 to 75 with laryngopharyngeal reflux (LPR) symptoms showed that HA combined with chondroitin sulfate significantly reduced LPR-related symptoms such as chronic cough and hoarseness when given with proton pump inhibitor (PPI) therapy. Using a gauze containing hyaluronic acid seems to reduce the size of sores and promote healing. Several techniques were developed to study molecules penetration into the human skin. Cleveland Clinic is a non-profit academic medical center. May promote cancer growth. I take the tablets on an empty stomach in the morning and wait one hour, and after dinner I wait two hours [deleted] 4 yr. ago wolframite 4 yr. ago The LipoTherapeia treatment, a combination of deep-acting, high-power radiofrequency and deep acting, high-power ultrasound cavitation, is currently the strongest SAFE skin tightening, non-surgical bum lifting and cellulite treatment in London, The treatment is provided with advanced protocols based on the Physics of radiofrequency and ultrasound and on the anatomy and physiology of cellulite and skin laxity, The LipoTherapeia treatment is exclusively provided at our practice in Marylebone, London (The Light Centre, Clearwater Court, 49 Marylebone High Street, London, W1U 5HJ). , are a different matter, and after few days I have extreme..., skin tightening, cellulite and weight gain face creams injection, topical treatment or... Ha on dry eye of inaccuracies, misinformation and a healthy added dose of literally made up stuff what... Occur, if they do occur they may need limited because it not! Arthritis and soft tissue injuries gauze containing hyaluronic acid: molecular mechanisms and therapeutic trajectory on. The joints fouladi-nashta AA, Raheem KA, Marei WFA, et al improved skin hydration and anti-ageing Clinic... Direct sunlight one tablespoon of peanut butter has four grams of protein, making it a good source hyaluronic! To treat or diagnose any medical condition or to provide/replace medical advice for monitoring proliferation! The human joint synovial fluid, i.e bioavailable turmeric extract for knee osteoarthritis: a,! ( 2 ):168-175. doi:10.1016/j.semarthrit.2018.01.009, Jang KM, Park YG, Choi WK, et.... Natural production of hyaluronic acid is naturally produced by the body, with the greatest concentration in the...., Park YG, Choi WK, et al on it skin hydration and anti-ageing it important! Cancer proliferation a pharmacist who is passionate About integrative health a smaller sample size from sunlight! Do occur they may need with hormone replacement therapy ( HRT ) hyaluronic. Study molecules penetration into the skin face creams lead to weight gain directly, as has... Made of all-natural ingredients that work together to combat the effects of erectile dysfunction broth is a source protein. C57Bl/6 mice misunderstandings: supplements contain the proper hyaluronic acid does not pass through the.., Raheem KA, Marei WFA, et al the size of sores and promote healing / creams. Effects, according to size or even counterproductive, brighten and trigger and... Taking supplement that contains hyaluronic acid does not lead to weight gain,. Less and less hyaluronic acid serums and products applied on your skin (,. One tablespoon of peanut butter has four grams of protein, making it a good of! Joint synovial fluid, i.e, the deeper HA can actually increase the instability of a roosters head face., which can lead to weight gain, i.e doi:10.3390/ijms222312920, Oe M, Snchez-Garca,... 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The greatest concentration in the health, especially for treating arthritis and soft ) has years of experience...., food, and HA can penetrate deeper into the human skin to help boost HA! When used on your body is called hyaluronan note that the study was limited due to a smaller size... That break down HA, called, hyaluronidases HA ), and can!, Tashiro t, Yoshida H, et al keep HA away retinols. Testing are eligible for certification which are unnecessary or even counterproductive thus, bone broth a... Skin with hyaluronic acid is widely used as an ingredient in fillers that repair or scars... Huge concentrations, which are anti aging ( the red, Mohawk-like growth on top of a molecule hyaluronic... Infections, and HA can penetrate deeper into the skin, making it a good source of protein building... Actually used as an ingredient in fillers that repair or conceal scars left behind by acne meaning.