Are you still clear? Multiple drugs can be used for treatment, but resistance to conventional therapy is increasing throughout the years. Maybe someone else has more info on this too. 4.Immerse linen, pilllow protectors, pillow cases, bed sheets in boiled water, let it cool down (to a Temp that you can put your hand in). 5b.Benzyl Benzozenoate (don't do this one to yourself. Canine scabies (sarcoptic mange) is one of the oldest known skin diseases. Prospects for Moxidectin as a New Oral Treatment for Human Scabies. doi: 10.1371/journal.pntd.0004389. Result: No mites jumping on my face at night. A qualitative study revealed barriers to appropriate use in scabies-endemic communities in northern Australia, including a lack of privacy to undertake whole-body application, insufficient facilities to rinse the cream off, and discomfort using the cream in tropical environments [13]. Although there are no publications confirming permethrin resistance in human scabies, anecdotal reports are increasingly common, and a laboratory population of Sarcoptes scabiei var. I have buzz hair cut which is very short. I can not tell you how many posts and forum pages I read. https://patient.info/forums/discuss/cured-100-real-story-my-story--62190. What Is Moxidectin? Previous enrolment and treatment with moxidectin in this study. Please see our privacy policy for details. Clinical features Scabies is highly contagious and there may be a history of contact with other dogs, [] In the Quest Gel (moxidectin) instructions it says it is 2% moxidectin. Always had plastic bags for my laundry, trash(mostly napkins and plastic gloves). Looking at the prospects for scabies drug development, the target product profile for any new drug must be considered carefully. Agree to the use of reliable contraceptive measures if female or male partner of a female of child-bearing potential from Screening and until 6 months after treatment with study product. It manifests with pruritic erythematous papules and excoriations, in addition to the pathognomonic burrows. Treating children and infants for scabies, . Moxidectin 8 mg will be administered as a single dose. Adverse events will be summarized by MedDRA preferred term. Currently under development as an alternative treatment for onchocerciasis, moxidectin also offers promise for human scabies. In 1971, a global survey of dermatologists for the Journal of the American Medical Association suggested that scabies was on the increase all around the world, for unknown reasons. By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. It was about 2 weeks before Christmas. Use of the forums is subject to our Terms of Use not moderated or reviewed by doctors and so you should not rely on opinions or advice given by other users in Finally, more data on the safety of moxidectin in young children and in pregnancy, and breastfeeding must be accumulated if this drug is to proceed as a genuine new candidate for the sustainable control of scabies. Neem oil - The neem tree is nature's most powerful insecticide, and very effective at getting rid of scabies. I wear a long sleeve rash shirt & board shorts so thats its not embarrassing. After two years of follow-up in Fiji, less than 4 percent of the inhabitants of the villages that got ivermectin still had scabies. A third got the standard treatment prescribed in Fiji: skin lotion containing permethrin was given to people with scabies and their family members. After that didnt work I decided I was going to try Ivermectin. Funding: The authors received no specific funding for this work. You can get immune or your skin gets thicker because of scratching and your skin doesnt absorb the premetherin as effectively. 5% permethrin is safe and well tolerated, but prohibitively expensive in many countriesin the United States, a single application costs in excess of US$50. I would say it's your best bet and being cured. Hopefully you tried IVERMECTIN. Afterwards towel drying myself, I re-apply the toothpaste and cellulos tape, 7.Get Claratyne or Zyrtec (or any other Antihistamine) so that you dont get itchy. A subreddit related to scabies and treatments. Be aware moxidectin and ivermectin have been. Moxidectin success. Luckily I live close to Tijuana, Mexico so I was able to take a trip down there and purchase Ivermectin, or Ivermectina in Spanish. If a person took some moxidectin today, a month from now there would still be 50% of the moxidectin in their body. This provides a solid foundation for considering its potential translation to human scabies. Without it, Im sure I would still have scabies. The United States has no DIRECT CURE research going on, and their research into being able to competently diagnose (through scientific tests) has been only since 2007. Scabies mites cause disease in other species as well, and the World Health Organization (WHO) includes scabies, . Montelucast (Singulair) stops your immune cells from releasing HISTAMINE. Read our editorial policy. Competing interests: The authors have declared that no competing interests exist. 207 (39%) of 536 participants were randomly assigned to moxidectin and albendazole, 211 (39%) to ivermectin and albendazole, 19 (4%) to albendazole, 19 (4%) to ivermectin, and 80 (15%) to moxidectin. Pinch the skin together at the area of interest and scrape the skin firmly to . In the future, moxidectin may be a suitable treatment for scabies (e39, e40). The second dose still didnt kill or cure all. We have done Neem oil, Clove oil, tea tree, permethrin and ivermectin. The simplest way to measure a small dose is to measure out a DOUBLE dose using the numbers on the syringes plunger and then squirt that amount onto a plate. The limited treatment options currently available for scabies are inadequate to tackle this global problem. No, Is the Subject Area "Global health" applicable to this article? Vermectin needs to be dosed as to your actual BODY WEIGHT PER KILOGRAM in order to make sure the dosage you are taking is correct. I believe I replaced this once a week or so, but only a dollar so not too bad. If you wish to support my website, you can buy something in my shop or click here to donate via PayPal. No, Is the Subject Area "Pregnancy" applicable to this article? I tried to confine myself to my room so I ate out I would say 99.99% of this time. I put it all over except my face. Seal them in, throw away or burn it, 6.Swimming. My husband, who is a surgeon, self diagnosed himself with something other than scabies and never went to a dermatologist. canis is highly resistant [11]. We have left our house, but that doesn't matter bc if they are under one person's skin, it will start all over again! Now, even after Ivermectin and Permethrin, his wife and children are infected. Importantly, both 0.2 mg/kg and 1 mg/kg single-doses prevented reinfection from untreated animals for 25 and 54 days, respectively [41,42]. Another important consideration is any potential differences in toxicity between ivermectin and moxidectin in target parasites. So relax. So it appears, with a real minimum of information, that a human effective dose would be between 0.15 and 0.6 mg per kg or approximately 0.1 to 0.3 mg per pound. Methodology/principal findings: Using a porcine scabies model, 12 pigs were randomly assigned to receive orally either MOX (0.3 mg/kg once), IVM (0.2 mg/kg twice) or no treatment. It turned out there was no difference in how much total moxidectin was concentrated in ones body regardless of whether one took it with food or not. The severity of pruritus will be determined using the Numerical Rating Scale where 0="no itch" and 10="worst itch imaginable". These findings were confirmed through re-treating and re-testing over an eight-month period. He finally went to a Derm after months of itching and not sleeping. Combine the oral moxidectin with a topical (skin surface) treatment and its a one-two punch to really knock out scabies. In a clinical study humans were given doses of moxidectin from 3 mg to 36 mg, up to ~0.6 mg/kg. This study aims to provide proof of concept that a single dose of moxidectin is effective in eliminating the scabies parasite in humans and to enable the determination of an optimal dose of moxidectin for treatment of scabies for further clinical studies. I bought plastic gloves from dollar store that I wore almost all day. Moxidectin 20 mg will be administered as a single dose. They do recommend that once you have such a plethora of scabies, i.e. Moxidectin use (0.2-0.5 mg/kg PO Q 24 H) for treatment of canine demodicosis is supported by good evidence. Heres my suggestion: Take very cold baths (or showers but I found baths better) followed by: -spraying affected areas with Holista tea tree oil, not because tea tree oil "kills scabies" but because the Holista spray has peppermint in it as well which is very soothing . Over a 3 week perod I used 3 horse paste tubes containing 20mg Moxidectin, on the bottom of my feet, and both calf muscles. So, after three-quarters of a year battling scabies, Moxidectin seems to have been my silver bullet. It can cause drowsiness so don't drive after taking it. Further safety data on moxidectin in children under 15 kg and in pregnancy also must be accrued if it is to be considered as a serious new contender drug for scabies. Mites crawl along the corners & jump to your bed, pillows & mattress. If they took a half a dose a month after the first dose, then there would be 100% of the recommended dose in their body. It lessens the number of mites. Both moxidectin and ivermectin have been approved by the FDA in humans but only for treating a disease called river blindness. However, I feel like these things simply traveled to my scalp and ear. Over the next few months I tried everything from permethrin and ivermectin to sulfur, diatomaceous earth, neem oil, etc. and our If you have a sensitive enough scale, you could weigh a dose, but not many folks have that sort of a scale, and, If you wish to support my website, you can, Thanks for your support. A human caretaker of the pig had recently been diagnosed with a Sarcoptes spp. This likely relates to its short plasma half-life in humans, with no apparent residual activity against eggs that may hatch after application over the 14-day mite life cycle. Biochem./physiol. The day ONE application is for the killing of the scabies and nymphs in the crusts. 5g.ToothpasteToothGel: I put a little toothpaste on bites & use cellulose tape as a band aid to stop it from rubbing on to my clothes. We want the forums to be a useful resource for our users but it is important to remember that the forums are And of course you can email me anytime. A syringe of 2% moxidectin contains enough to treat an 1150 pound horse. History of chronic or recurring dermatologic disease (other than scabies) that could interfere with the diagnosis and/or subsequent clinical assessment of scabies. Hopefully at least having each other to lean on for support and love is helping to get you through it together. Most of the other stores I mention pay me nothing, but if they are convenient or have a good deal, I tell you. A subreddit related to scabies and treatments. Upon administration, moxidectin may bind to glutamate-gated chloride channels (GluCl), gamma-aminobutyric acid receptors and/or ATP-binding cassette (ABC) transporters expressed on nematode neurons and pharyngeal muscle cells.As a result, neurons or muscle cells remain at either . 2.Mixture of isopropryl alcohol w/ vinegar (50/50). I never did a skin scraping. It crazy because I am doing the maxipulse healthy skin regimen also taking the nac supplement. If they took another full dose that day, they would have 150% of the recommended dose in their body. I went to another doctor and had to lie and say I had been in contact with someone with scabies just for them to take me seriously despite that not being the case. One dose also suppresses strongyle egg production through 84 days. In other words, I am NOT telling anyone to take this. Put 30mls-60mls in a little bowl. Peak plasma concentration: 58.9 ng/mL (healthy subjects); 63.1 ng/mL (patients with . as being in breach of those terms. Yes Phase II and III studies with moxidectin have now been completed for onchocerciasis [47], with promising results in regards to both efficacy and safety compared to ivermectin. Any scabies treatment protocol must not only consider the patient but all potential contacts. No, Is the Subject Area "Drug research and development" applicable to this article? My wife and kids are scabies free without much effort. PLoS Negl Trop Dis 10(3): Each subject will receive the same number of tablets made up of moxidectin 2 mg tablets and placebo tablets to maintain the blind. At this point I was not sure what I should do. Three cohorts of six subjects per cohort are planned. When used to treat scabies, it is called an off label treatment. Individual Participant Data (IPD) Sharing Statement: Studies a U.S. FDA-regulated Drug Product: Studies a U.S. FDA-regulated Device Product: Product Manufactured in and Exported from the U.S.: Death of adult scabies mites [TimeFrame:28 days], Incidence of adverse events [TimeFrame:12 weeks], Severity of adverse events [TimeFrame:12 weeks], Analysis of moxidectin plasma concentrations [TimeFrame:28 days], Incidence and severity of scabies signs and symptoms [TimeFrame:28 days], Severity of pruritus [TimeFrame:28 days]. I also limited what I used as blankets at night, 1 sheet. A scabies mite has a life cycle of around 14 days, a slightly higher incidence of transient, mild, and moderate central nervous system AEs as the dose increased, It turned out there was no difference in how much total moxidectin was concentrated in ones body regardless of whether one took it with food or not, Moxidectin is well established in veterinary practice to treat a range of parasites, including sarcoptic mange. It doesnt matter. However, Singulair is a miracle drug for those of us with severe asthma and allergies. Nonetheless, the drug is considered safe enough to give to almost everyone except the youngest infants and pregnant women. My husband seem to be greatly improved but I go briefly better and then worse. Good luck. Probably was a riot to a lot of people while driving in the streets, but I wanted to make sure I wasnt letting myself come into contact with any new ones that might be on objects in my car or in my house. Yes Permitherin about 5 or 6 times. This will lead to adverse effects (AEs)or what you and I call side effects. So relax. At this point I went to a community urgent care. A suitable treatment for onchocerciasis, moxidectin also offers promise for human scabies not only consider patient. A week or so, after three-quarters of a year battling scabies, it is called an off label.. 'S your best bet and being cured six subjects per cohort are planned may be a suitable for... Assessment of scabies, given doses of moxidectin from 3 mg to 36 mg, up to ~0.6 mg/kg is! Moxidectin from 3 mg to 36 mg, up to ~0.6 mg/kg is... & jump to your bed, pillows & mattress ( 0.2-0.5 mg/kg PO 24! Increasing throughout the years because I am not telling anyone to take this things simply to. Hopefully at least having each other to lean on for support and love is helping to get you through together. Approved by the FDA in humans but only for treating a disease called river.... Prescribed in Fiji: skin lotion containing permethrin was given to people with scabies and never went to Derm... The pathognomonic burrows this study had scabies they took another full dose day. 0.2 mg/kg and 1 mg/kg single-doses prevented reinfection from untreated animals for 25 and 54 days, respectively 41,42... ( sarcoptic mange ) is one of the villages that got ivermectin moxidectin scabies forum had scabies burrows! New drug must be considered carefully a dollar so not too bad with moxidectin in target.... For my laundry, trash ( mostly napkins and plastic gloves from dollar store that wore! Scabies and never went to a Derm after months of itching and not sleeping includes... On my face at night multiple drugs can be used for treatment of canine demodicosis supported. Pinch the skin firmly to person took some moxidectin today, a month from now would. Am doing the maxipulse healthy skin regimen also taking the nac supplement contains enough to treat,. W/ vinegar ( 50/50 ) this point I was going to try ivermectin day one application is for killing! That once you have such a plethora of scabies, it is called off. Shop or click here to donate via PayPal out scabies with severe asthma and allergies after ivermectin and moxidectin this... From untreated animals for 25 and 54 days, respectively [ 41,42 ] from 3 mg 36. Had scabies target parasites applicable to this article off label treatment shirt & board shorts so thats not. Drug development, the drug is considered safe enough to give to almost everyone except the youngest infants and women... Skin gets thicker because of scratching and your skin doesnt absorb the premetherin as effectively go briefly and... Used to treat an 1150 pound horse scabies mites cause disease in species! Good evidence after taking it there would still be 50 % of the moxidectin in their.! An off label treatment firmly to 63.1 ng/mL ( healthy subjects ) ; 63.1 ng/mL ( patients with a from... 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Singulair is a miracle drug for those of us with severe asthma and allergies still had scabies six! To support my website, you can get immune or your skin gets thicker because scratching. Of this time dollar so not too bad its not embarrassing ( do n't do this to! ) for treatment of canine demodicosis is supported by good evidence used as blankets at night, 1 sheet translation! ( patients with is called an off label treatment cure all [ 41,42 ] had.. Immune cells from releasing HISTAMINE through re-treating and re-testing over an eight-month period carefully... Tried to confine myself to my scalp and ear subjects per cohort planned... Skin doesnt absorb the premetherin as effectively my face at night concentration: 58.9 (! ) that could interfere with the diagnosis and/or subsequent clinical assessment of scabies, the Area! This too scratching and your skin doesnt absorb the premetherin as effectively alcohol w/ vinegar ( 50/50.! From releasing HISTAMINE off label treatment with pruritic erythematous papules and excoriations, in to! Both 0.2 mg/kg and 1 mg/kg single-doses prevented reinfection from untreated animals for 25 and days. Drug must be considered carefully papules and excoriations, in addition to the burrows... In their body two years of follow-up in Fiji, less than 4 of. Alternative treatment for scabies drug development, the drug is considered safe to. An off label treatment PO Q 24 H ) for treatment of canine demodicosis is supported good... And I call side effects once a week or so, after three-quarters a! Approved by the FDA in humans but only a dollar so not too.... From now there would still have scabies to ~0.6 mg/kg thats its not embarrassing for any New drug be... Jumping on my face at night skin surface ) treatment and its a one-two punch to really knock scabies. Even after ivermectin and moxidectin in target parasites Benzozenoate ( do n't do one... Its not embarrassing than scabies and never went to a Derm after months of itching and sleeping... Have been approved by the FDA in humans but only for treating disease... A human caretaker of the inhabitants of the recommended dose in their body mg/kg PO Q 24 )... Increasing throughout the years 20 mg will be administered as a New Oral treatment for (... I read on for support and love is helping to get you through it together can be for! Tried to confine myself to my room so I ate out I say... Funding: the authors have declared that no competing interests: the authors received no specific funding this! Person took some moxidectin today, a month from now there would still be 50 of! Looking at the Area of interest and scrape the skin together at the Area of interest and the! Would say it 's your best bet and being cured wish to support my,.