A proprietary aqueous S. barbata extract appears to target tumor mitochondria to induce ROS generation and DNA damage followed by PARP hyperactivation, cellular ATP and NAD depletion, and glycolysis inhibition(33). With cancer, where you get treated first matters. Pharmacist's Letter/Prescriber's Letter. View abstract. View abstract. View abstract. The pharmacology of Chinese herbs. Drugs 2005;65(9):1239-1282. Kaplya, O. CNS.Neurol.Disord Drug Targets. Zeng H.Y and Praveen K.S. Jiang, R. H., Su, W. C., Liu, H. F., Huang, H. S., and Chao, J. I. Supplementing with skullcap may provide several health benefits, such as improved mood, reduced inflammation, and anticancer effects. Flavocoxid, a dual inhibitor of cyclooxygenase and 5-lipoxygenase, blunts pro-inflammatory phenotype activation in endotoxin-stimulated macrophages. Tseng-Crank J, Sung S, Jia Q, and et al. Int Immunopharmacol. Wu X, Zhang H, Salmani JM, et al. View abstract. vitamins, herbs, dietary supplements a-z list. Lei, W., Sun, M., Luo, K. M., Shui, X. R., Sun, Y. M., and Tang, H. [Compute simulation to characterize structure and function of chalcone synthase from Scutellaria baicalensis Georgi]. Blood 2-15-2008;111(4):2354-2363. Ye, F., Jiang, S., Volshonok, H., Wu, J., and Zhang, D. Y. Molecular mechanism of anti-prostate cancer activity of Scutellaria baicalensis extract. The root is used to make medicine. To avoid any Vopr.Onkol. 2009;29(1):211-213. Badaoui A. Allergic contact dermatitis to resveratrol and Scutellaria baicalensis root extract in a cosmetic product. The effect of herbal medicine baicalin on pharmacokinetics of rosuvastatin, substrate of organic anion-transporting polypeptide 1B1. Sensitisation of ovarian cancer cells to cisplatin by flavonoids from. It's one of the most commonly used thickeners and emulsion stabilizers.If the product is too runny, a little xanthan gum will make it more gel-like. Z., Qin, B. W., Cheng, J. J., and Miao, H. Effect of Scutellaria flavonoids on KCN-induced damages in rat pheochromocytoma PC12 cells. View abstract. Planta Med 2000;66(8):694-698. This Web site is not to be used as a substitute for medical advice, diagnosis or treatment of any health condition or problem. Safety, tolerability, pharmacokinetics, and food effect of baicalein tablets in healthy Chinese subjects: A single-center, randomized, double-blind, placebo-controlled, single-dose phase I study. View abstract. Studies indicate that aqueous extracts suppressed the growth of lymphoma and myeloma cells. J Dermatol Sci 2007;46(1):31-40. The flavonoid baicalin exhibits anti-inflammatory activity by binding to chemokines. Z., Bai, L., Chen, D. G., Xu, Q. T., and Southerland, W. M. Computational investigation of the anti-HIV activity of Chinese medicinal formula Three-Huang Powder. Reichenbach S, Juni P. Medical food and food supplements: not always as safe as generally assumed. Tyrosinase is a key enzyme involved in the synthesis of melanin, the pigment that gives skin color. Altavilla D, Squadrito F, Bitto A, et al. WebScutellaria Baicalensis Root - China Manufacturers, Factory, Suppliers. View abstract. Kaplya, O. Preliminary study of traditional Chinese medicine treatment of minimal brain dysfunction: analysis of 100 cases. Phytomedicine. In theory, Baikal skullcap might increase the risk of bruising and bleeding in people with bleeding disorders. Available at: https://www.cancer.gov/about-cancer/treatment/cam/hp/pc-spes-pdq. View abstract. Phase I trial and antitumor effects of BZL101 for patients with advanced breast cancer. But there is not enough information to know if Baikal skullcap is the cause of these side effects. View abstract. Further studies are needed. Intern Med 2001;40:764-8. Z., Qin, B. W., Cheng, J. J., and Miao, H. Effect of Scutellaria flavonoids on KCN-induced damages in rat pheochromocytoma PC12 cells. 7-1-2005;382(1-2):71-75. Kimura, Y. and Sumiyoshi, M. Effects of baicalein and wogonin isolated from Scutellaria baicalensis roots on skin damage in acute UVB-irradiated hairless mice. View abstract. Differential interaction of 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors with ABCB1, ABCC2, and OATP1B1. View abstract. View abstract. 12-10-2008;8(12):1652-1657. Biol Pharm Bull 2004;27(10):1580-1583. 2003;34(3):504-506. 11-12-2009;126(2):320-331. Your lithium dose might need to be changed. View abstract. Immunopharmacology 2000;49:295-306. Nutr Res 2009;29:298-304. Bezielle selectively targets mitochondria of cancer cells to inhibit glycolysis and OXPHOS. Quality evaluation of commercial extracts of Scutellaria baicalensis. View abstract. It's famous for containing anti-inflammatory natural salicylates (this powder, for example, is standardized to contain 53-65%), a close chemical relative to famous exfoliant salicylic acid.. View abstract. 1989;35(3):331-335. 1997;52(11-12):817-823. This is especially relevant to macrophages and immune cells. numbuzin No.3 Porcelain Base-skip Tone Up Beige ingredients explained: Water, Zinc Oxide, Cyclohexasiloxane, Propanediol, Propylheptyl Caprylate, Caprylyl Methicone, Trimethylsiloxysilicate, Polyglyceryl-3 Polydimethylsiloxyethyl Dimethicone, Titanium Dioxide, Niacinamide, Disiloxane, Butyloctyl Salicylate, Centella Asiatica View abstract. View abstract. Life Sci 10-27-2000;67(23):2889-2896. J Ethnopharmacol. Hirunuma, M., Shoyama, Y., Sasaki, K., Sakamoto, S., Taura, F., Shoyama, Y., Tanaka, H., and Morimoto, S. Flavone-catalyzed apoptosis in Scutellaria baicalensis. Lung inflammation due to bacterial or viral infection, Elevated high-sensitivity C-reactive protein and high triglycerides. Kang, T. H., Hong, B. N., Park, C., Kim, S. Y., and Park, R. Effect of baicalein from Scutellaria baicalensis on prevention of noise-induced hearing loss. View abstract. Here we will discuss the prominent benefits and side effects of the ScutellariaBaicalensisExtractBaicalin herb produced in China. Scutellaria baicalensis is a Chinese root extract used in several traditional medicines to treat different problems. In that case, it is either used for hormone synthesis or hormone breakdown, including estrogen and testosterone, which are not advised to combine with the Chinese herb. View abstract. 2007;60(5-6):294-297. 2-1-2010;84(2):137-144. View abstract. Thanks to its salicin content, willow bark is often touted as Select a condition to view a list of vitamins. A., Attele, A. S., Zhang, L., and Yuan, C. S. Anti-HIV activity of medicinal herbs: usage and potential development. High temperature effects on flavones accumulation and antioxidant system in Scutellaria baicalensis Georgi cells. View abstract. Some of these medications that are changed by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline, zileuton (Zyflo), zolmitriptan (Zomig), and others. A Medicinal Plant Extract of Scutellaria Baicalensis and Acacia Catechu Reduced LPS-Stimulated Gene Expression in Immune Cells: A Comprehensive Genomic Study Using QPCR, ELISA, and Microarray. View abstract. Morgan SL, Baggott JE, Moreland L, et al. View abstract. Am J Chin Med 2008;36(3):517-540. Linnebur, S. A., Rapacchietta, O. C., and Vejar, M. Hepatotoxicity associated with chinese skullcap contained in Move Free Advanced dietary supplement: two case reports and review of the literature. This could change the effects and side effects of these medications. J Ethnopharmacol. Metformin (Glucophage) is used to help decrease blood sugar. Kong XT, Fang HT, Jiang GQ, et al. Journal of China Pharmacy 2010;21. View abstract. Whether co-administration of garlic has negative influence on Scutellaria baicalensis Georgi in treating models rats with pelvic inflammation? The ethanol extract of Scutellaria baicalensis and the active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and Bax in human lung cancer cells. Mu, R., Qi, Q., Gu, H., Wang, J., Yang, Y., Rong, J., Liu, W., Lu, N., You, Q., and Guo, Q. 2008;57(3):111-114. Preclinical studies of S. barbata have focused mostly on colon, lung, and liver cancer models. Hu, Z., Yang, X., Ho, P. C., Chan, S. Y., Heng, P. W., Chan, E., Duan, W., Koh, H. L., and Zhou, S. Herb-drug interactions: a literature review. This Web site is not to be used as a substitute for medical advice, diagnosis or treatment of any health condition or problem. Another Scutellaria Baicalensis Root Extract trade name mixture (90% ethanol and butylene glycol extract) Guang.Pu.Xue.Yu Guang.Pu.Fen.Xi. View abstract. Flavocoxid is as effective as naproxen for managing the signs and symptoms of osteoarthritis of the knee in humans: a short-term randomized, double-blind pilot study. Diabetes medications are also used to lower blood sugar. Lam, T. L., Lam, M. L., Au, T. K., Ip, D. T., Ng, T. B., Fong, W. P., and Wan, D. C. A comparison of human immunodeficiency virus type-1 protease inhibition activities by the aqueous and methanol extracts of Chinese medicinal herbs. Zhongguo Zhong.Yao Za Zhi 2009;34(21):2803-2807. [Effects of light on flavonoids accumulation and related gene expression in suspension cultures of Scutellaria baicalensis]. The ethanol extract of Scutellaria baicalensis and the active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and Bax in human lung cancer cells. View abstract. View abstract. View abstract. Chalasani N, Vuppalanchi R, Navarro V, et al. Levy RM, Saikovsky R, Shmidt E, et al. J Neurochem. Lin H, Zhou J, Lin K, et al. Chan, F. L., Choi, H. L., Chen, Z. Y., Chan, P. S., and Huang, Y. View abstract. J Ethnopharmacol. Udintsev, S. N., Razina, T. G., and Iaremenko, K. V. [The antitumor effect of Baikal skullcap]. [Clinical and experimental study on inhibitory effect of sanhuang mixture on platelet aggregation]. Yance, D. R., Jr. and Sagar, S. M. Targeting angiogenesis with integrative cancer therapies. Effects of Mg-ATP on the flavonoid production in the Scutellaria baicalensis Georgii suspension cultures. View abstract. Alcohol: Alcohol interacts with Baicalin and can cause some serious Skullcap side effects like drowsiness, dizziness, and sleepiness. Larger studies in humans that test safety and effectiveness are needed to determine under what circumstances S. baicalensis may be beneficial. Pasanen MK, Fredrikson H, Neuvonen PJ, Niemi M. Different effects of SLCO1B1 polymorphism on the pharmacokinetics of atorvastatin and rosuvastatin. View abstract. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. African Journal of Biotechnology 2011;10(26):5182-5192. Konig J, Seithel A, Gradhand U, Fromm MF. Chinese Journal of Gerontology 2010;30(7):926-928. Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, indomethacin (Indocin), ticlopidine (Ticlid), warfarin (Coumadin), and others. View abstract. This information may not fit your specific health circumstances. Kimura, Y., Yokoi, K., Matsushita, N., and Okuda, H. Effects of flavonoids isolated from scutellariae radix on the production of tissue-type plasminogen activator and plasminogen activator inhibitor-1 induced by thrombin and thrombin receptor agonist peptide in cultured human umbilical vein endothelial cells. Memorial Sloan Kettering does not record specific website user information and does not contact users of this website. View abstract. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 73.^ Hwang YK, Jinhua M, Choi BR, Cui CA, Jeon WK, Kim H, Kim HY, Han SH, Han JS Effects of Scutellaria baicalensis on chronic cerebral hypoperfusion-induced memory impairments and chronic lipopolysaccharide infusion-induced memory impairments J Ethnopharmacol. In addition, it can reduce inflammation in the body can easily heal liver toxicity, and can detoxify the body. Anticonvulsant effect of wogonin isolated from. Studies on inhibitors of skin tumor promotion. View abstract. Guangxi Zhiwu 2008;28(3):373-378. Therefore, if you are a diabetic patient, you should stay away from such herbs. Visit the FDA MedWatch website or call 1-800-FDA-1088. In vitro, the flavonoid baicalin exhibits anti-inflammatory, antioxidant, and gram-positive antibacterial activity(3). 1-8-2007;245(1-2):269-274. Vopr.Onkol. J Med Food 2009;12:1143-8. J Ethnopharmacol. How It Works Purported Uses and Benefits Do Not Take If Side Effects Special Point Back to top For Takahashi, H., Chen, M. C., Pham, H., Angst, E., King, J. C., Park, J., Brovman, E. Y., Ishiguro, H., Harris, D. M., Reber, H. A., Hines, O. J., Gukovskaya, A. S., Go, V. L., and Eibl, G. Baicalein, a component of Scutellaria baicalensis, induces apoptosis by Mcl-1 down-regulation in human pancreatic cancer cells. View abstract. Efficacy and safety of flavocoxid, a novel therapeutic, compared with naproxen: a randomized multicenter controlled trial in subjects with osteoarthritis of the knee. Ong, E. S., Len, S. M., and Lee, A. C. Differential protein expression of the inhibitory effects of a standardized extract from Scutellariae radix in liver cancer cell lines using liquid chromatography and tandem mass spectrometry. Most of the studies related to Scutellaria baicalensis are done in the laboratory and not on real humans. But there is not enough information to know if Baikal skullcap is the cause of these side effects. Some medications are changed and broken down by the liver. Kimura, Y., Matsushita, N., Yokoi-Hayashi, K., and Okuda, H. Effects of baicalein isolated from Scutellaria baicalensis Radix on adhesion molecule expression induced by thrombin and thrombin receptor agonist peptide in cultured human umbilical vein endothelial cells. OTHER NAME(S): Baicalein, Baikal Scullcap, Baikal Skullcap Root. Next to red peppers, you can get the most vitamin C from ________________. Biull.Eksp.Biol Med 1999;128(9):327-329. Lin, X. C., Liu, X. G., Chen, X. W., Chen, W. Z., and Liang, N. C. [Inhibitory effect and its kinetic analysis of baicalein on recombinant human protein kinase CK2 holoenzyme]. Low blood pressure: Baikal skullcap might lower blood pressure. Hong, T., Jeong, M. L., Zahn, M., Fay, B. Zhang H and Huang J. J Cell Biochem 10-1-2010;111(2):274-283. Scutellaria baicalensis Georgi extracts inhibit RANKL-induced osteoclast differentiation. Due to such properties, it is found that this medicine is prominent in dealing with cancer-producing cells. Scutellaria baicalensisis used in traditional medicine to treat many medical conditions, but studies in humans are limited.S. Baikal skullcap is POSSIBLY SAFE for most adults when taken by mouth. Shang, Y. Any questions regarding your own health should be addressed to your own physician or other healthcare provider. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using. Morgan SL, Baggott JE, Moreland L, et al. Biomed Res Int 2016;2016:5697571. Side effects are few and may include drowsiness. Elevated high-sensitivity C-reactive protein and high triglycerides were possibly related to ingestion of baicalein tablets in healthy subjects and should be monitored in future studies(25). WebThe root of Scutellaria baicalensis is used as medicine. Mol Urol. Guo, H. X., Liu, D. H., Ma, Y., Liu, J. F., Wang, Y., Du, Z. Y., Wang, X., Shen, J. K., and Peng, H. L. Long-term baicalin administration ameliorates metabolic disorders and hepatic steatosis in rats given a high-fat diet. Zhou, J., Qu, F., Zhang, H. J., Zhuge, X. H., and Cheng, L. Z. View abstract. Be sure to follow relevant directions on product labels and consult a, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Bird Flu Deaths Prompt U.S. to Test Vaccine in Poultry, COVID Treatment in Development Appears Promising, Marriage May Help Keep Your Blood Sugar in Check, Getting Outdoors Might Help You Take Fewer Meds, New Book: Take Control of Your Heart Disease Risk, Getting Help for a Loved One With Psychosis: It's Complicated, Health News and Information, Delivered to Your Inbox, Attention deficit-hyperactivity disorder (ADHD), The Role Gut Bacteria Plays on the Overall Body. Taking Baikal skullcap along with estrogen pills might decrease the effects of estrogen pills. Xu, X. F., Cai, B. L., Guan, S. M., Li, Y., Wu, J. reduce wrinkles, smooth skin) but without the side effects (though it seems now that the INCI name of Lanablue was Safety, tolerability, and pharmacokinetics of oral baicalein tablets in healthy Chinese subjects: A single-center, randomized, double-blind, placebo-controlled multiple-ascending-dose study. Different effects of baicalein, baicalin and wogonin on mitochondrial function, glutathione content and cell cycle progression in human hepatoma cell lines. View abstract. A medicinal extract of Scutellaria baicalensis and Acacia catechu acts as a dual inhibitor of cyclooxygenase and 5-lipoxygenase to reduce inflammation. Birth Defects Res B Dev.Reprod.Toxicol. There are no known side effects of using scutellaria baicalensis root extract and it is considered gentle enough for sensitive skin types to use. View abstract. 2021 Mar;10(3):2979-2989. Baicalin also activated caspase-3, resulting in apoptosis of leukemia-derived T cells. Pursuing basic and translational research across 9 programs and 100+ labs, Focusing on clinical cancer research and population health, Bridging the lab and the clinic through translational research, Fostering interdisciplinary collaborations between laboratory scientists and clinicians, Partnering with other academic and research institutions, Offering state-of-the-art resources for our researchers, Offering a curriculum with a focus on cancer, Connecting college seniors to future careers in biomedicine, 2023 Memorial Sloan Kettering Cancer Center, Human Oncology & Pathogenesis Program (HOPP), Gerstner Sloan Kettering Graduate School of Biomedical Sciences, High school & undergraduate summer programs, Integrative Medicine at Home Membership Program, Characterization of chemical constituents in. View abstract. Hui KM, Wang XH, Xue H. Interaction of flavones from the roots of Scutellaria baicalensis with the benzodiazepine site. View abstract. Planta Med 1997;63(2):141-145. WebSkullcap (Scutellaria lateriflora ) is a plant native to the US and Europe. Hui KM, Wang XH, Xue H. Interaction of flavones from the roots of Scutellaria baicalensis with the benzodiazepine site. Scutellaria baicalensis extract containing baicalin (a flavone, type of flavonoid, is a major bioactive compound) has been used in traditional Some medications are moved by pumps into cells. Your lithium dose might need to be changed. View abstract. Cancer Res 7-15-2003;63(14):4037-4043. S. barbata also prevented liver injury by attenuating NF-kB-mediated inflammation and oxidative stress(31)and increasing superoxide dismutase levels(16). Baikal skullcap might make these pumps less active and increase how much of some medications get absorbed by the body. There have been reports of fever and lung inflammation in people who took Baikal skullcap. Int J Cancer 5-1-2007;120(9):2019-2027. View abstract. View abstract. View abstract. ]. Small studies also suggest it is safe and may benefit patients with advanced breast cancer(13)(14). Jiang, R. H., Su, W. C., Liu, H. F., Huang, H. S., and Chao, J. I. Antitumor activity of chloroform fraction of, In vitro anti-leukemic activity of the ethno-pharmacological plant. Planta Med 2010;76(7):678-682. Bioorg.Med Chem 8-1-2008;16(15):7516-7524. It is thought that the active chemicals in Baikal skullcap might be able to decrease inflammation, stop tumor growth, and prevent tumor cell reproduction. Some medications for high blood pressure include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), amlodipine (Norvasc), hydrochlorothiazide (HydroDIURIL), furosemide (Lasix), and many others. Monitor your blood sugar closely. Bonham, M., Posakony, J., Coleman, I., Montgomery, B., Simon, J., and Nelson, P. S. Characterization of chemical constituents in Scutellaria baicalensis with antiandrogenic and growth-inhibitory activities toward prostate carcinoma. 5. Taking Baikal skullcap along with sedative medications might cause too much sleepiness. Levy RM, Saikovsky R, Shmidt E, et al. View abstract. Scutellaria baicalensis extract containing baicalin (a flavone, type of flavonoid, is a major bioactive compound) has been used in traditional Chinese medicine to treat conditions of inflammation, hypertension, cardiovascular diseases, etc. View abstract. The effect of he jie decoction on the TCRV beta 7 of chronic hepatitis B patients. Cell Mol Biol Res 1993;39(2):119-124. Baikal skullcap might decrease blood sugar. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. View abstract. Baikal skullcap might also cause sleepiness and drowsiness. 2011;10(2):184-191. Pharmacotherapy 2010;30(7):750, 258e-750, 262e. View abstract. Lin, Y. L., Dai, Z. K., Lin, R. J., Chu, K. S., Chen, I. J., Wu, J. R., and Wu, B. N. Baicalin, a flavonoid from Scutellaria baicalensis Georgi, activates large-conductance Ca2+-activated K+ channels via cyclic nucleotide-dependent protein kinases in mesenteric artery. Smol'ianinov ES, Gol'dberg VE, Matiash MG, et al. RxList does not provide medical advice, diagnosis or treatment. The antiinflammatory and analgesic effects of baicalin in carrageenan-evoked thermal hyperalgesia. Adv Ther 2010;27:731-42. Blood 2-15-2008;111(4):2354-2363. Zhongguo Ying.Yong.Sheng Li Xue.Za Zhi 2009;25(3):344-348. The extract coming from the bark of the White Willow, a big (25 m/80 ft.) tree that likes to live on riverbanks. Effect of Scutellaria baicalensis extract on the immunologic status of patients with lung cancer receiving antineoplastic chemotherapy. J Ethnopharmacol. J Nat Prod 2009;72(9):1616-1619. NIH National Cancer Institute. Gao Z, Huang K, Yang X, Xu H. Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi. Mol Biol (Mosk) 2009;43(6):1082-1087. Clin Transl Sci 2021;14(5):2017-2024. 2011;10(2):184-191. Yoon, S. B., Lee, Y. J., Park, S. K., Kim, H. C., Bae, H., Kim, H. M., Ko, S. G., Choi, H. Y., Oh, M. S., and Park, W. Anti-inflammatory effects of Scutellaria baicalensis water extract on LPS-activated RAW 264.7 macrophages. Chen, H. H., Hong, H. J., Chou, Y. H., Cheng, T. H., Chen, J. J., and Lin, H. Inhibition of cyclic strain-induced endothelin-1 secretion by baicalein in human umbilical vein endothelial cells. Therapeutic Research Faculty 2020. Zhi 2009 ; 34 ( 21 ):2803-2807 D, Squadrito F, Bitto a, Gradhand U, MF! Most adults when taken by mouth and food supplements: not always safe. Zhou, J., Qu, F. L., Chen, Z. 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